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Poster AGBT 2014 – Active Deparaffinization Drives Superior Yields, Quality, and Sequencing Coverage from FFPE Tissue Samples
Tissue samples are commonly preserved by Formalin Fixation and Paraffin Embedding (FFPE) to allow for extended storage. Starting with cores, sections, or slides, paraffin is removed from the FFPE tissue sample by emulsification driven by the very finely controlled and reproducible acoustic energy provided by Covaris Focused-ultrasonicators.
Retrospective Application of Transposon-Directed Insertion Site Sequencing to a Library of Signature-Tagged Mini-Tn5Km2 Mutants of Escherichia coli O157:H7 Screened in Cattle
Massively parallel sequencing of transposon-flanking regions assigned the genotype and fitness score to 91% of Escherichia coli O157:H7 mutants previously screened in cattle by signature-tagged mutagenesis (STM). The method obviates the limitations of STM and markedly extended the functional annotation of the prototype E. coli O157:H7 genome without further animal use.
AFA-Nanocrystal™ Production Batch-scale (2mL) Cinnarizine (CNZ) Preparation Protocol Part number 010316
An RNA-Seq Strategy to Detect the Complete Coding and Non-Coding Transcriptome Including Full-Length Imprinted Macro ncRNAs
Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head using an optimized RNA-Seq strategy. The data produced is highly reproducible in different sequencing locations and is able to detect the full length of imprinted macro ncRNAs such as Airn and Kcnq1ot1, whose length ranges between […]
To exploit fully the potential of current sequencing technologies for population-based studies, one must enrich for loci from the human genome. Here we evaluate the hybridization-based approach by using oligonucleotide capture probes in solution to enrich for approximately 3.9 Mb of sequence target. We demonstrate that the tiling probe frequency is important for generating sequence […]
Wash Buffer Safety Data Sheet
(Safety Data Sheets )
During the development of DNA shearing protocols for Covaris Focused-ultrasonicators, the Agilent DNA 12000 kit was used to evaluate the average base pair (peak) size because of the large fragment size range this kit covers, encompassing the 130 bp to 5 kb range achievable with a Covaris system.
(Application Notes )
AFA-Nanoemulsion: Rice Bran Oil in Water 2 mL Protocol
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.