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Adaptive Focused Acoustics (AFA) was used to effectively disperse Pseudomonas aeruginosa biofilms and disrupt bacterial cells in a low detergent concentration lysis buffer, significantly increasing the efficiency of protein extraction. Biofilm specific staining with Calcoflour White M2R revealed that overnight cultures of Pseudomonas aeruginosa PA14 produce extensive biofilms, and counterstaining with the cell permeable SYTO […]
(Application Notes )
AFA-Liposome Formation: HSPC/PEGDSPE2000/Cholesterol Protocol
Heat-inactivated Preparation Protocol for Mycobacteria Colony Samples and Analysis on the Bruker MALDI Biotyper® MALDI-TOF Mass Spectrometer
truXTRAC MALDI-TOF MS Protocol for: Heat-inactivated Preparation Protocol for Mycobacteria Colony Samples and Analysis on the Bruker MALDI Biotyper® MALDI-TOF Mass Spectrometer
Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes
Massively parallel sequencing is a useful approach for characterizing T-cell receptor diversity. However, immune receptors are extraordinarily difficult sequencing targets because any given receptor variant may be present in very low abundance and may differ legitimately by only a single nucleotide. We show that the sensitivity of sequence-based repertoire profiling is limited by both sequencing […]
Evaluation of a New Protein Extraction Method Using an Advanced Acoustic Technology for Identification of Filamentous Fungi by MALDI-TOF MS
While matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) has become a mainstay for clinical labs to identify most bacteria and yeast, its application for filamentous fungi (mold) identification (ID) is still limited. In this study, we assessed a new protein extraction method that generated spectra suitable for MALDI-TOF MS using Adaptive […]
Journal of Proteome Research, 2015, Articles ASAP, Publication Date (Web): December 14, 2015 (Article) Tabb et. al. The NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC) employed a pair of reference xenograft proteomes for initial platform validation and ongoing quality control of its data collection for The Cancer Genome Atlas (TCGA) tumors. These two xenografts, representing […]
DNA Shearing with microTUBEs (<1.5kb fragments) S220/E220 Protocol
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.