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Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
We describe the genome sequencing of an anonymous individual of African origin using a novel ligation-based sequencing assay that enables a unique form of error correction that improves the raw accuracy of the aligned reads to >99.9%, allowing us to accurately call SNPs with as few as two reads per allele. We collected several billion […]
Application Note: Active Extraction of Native Proteins from Yeast using Covaris Adaptive Focused Acoustics (AFA)
Using yeast as a model organism, several commercially available native protein extraction reagents were tested for total protein yield and preservation of enzymatic activity using either a “passive extraction” method or an AFA-based “active extraction” method.
(Application Notes )
In honey bees (Apis mellifera) the behaviorally and reproductively distinct queen and worker female castes derive from the same genome as a result of differential intake of royal jelly and are implemented in concert with DNA methylation. To determine if these very different diet-controlled phenotypes correlate with unique brain methylomes, we conducted a study to […]
Protocol for: Tissue dry Pulverization using the CryoPrep™ CP02 Part Number 010303
Protein Extraction Buffer N Protocol Part number 010170
To enhance efficiency of the lead optimization process at Bayer CropScience, a high-throughput HPLC/MS-laboratory for the purification of up to 48 crude products per day in the range of 200−400 mg each in one injection per sample has been set up. The use of Covaris technology for HPLC sample preparation, automated aliquotation during fractionation, and […]
User Manual for: t-PREP™ Biomarker Extraction System User Manual Part Number 010164
(User Manuals )
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.