The next generation single-tube blood collection, stabilization, transport, and biomarker extraction solution
Biomarker extraction from blood is the method of choice for researchers and clinicians, but the logistics of blood collection, stabilization, shipping, and biomarker extraction remain complex, expensive, and difficult to standardize. Blood collection methods for biomarker extraction require a professional phlebotomist, collection of large volumes of blood, and leak-proof overnight shipping on ice or cold-packs. This creates logistic and financial barriers for emerging biomarker application such as large scale genomic, pharmaceutical pre-clinical, and animal model studies. For example, the novel truCOLLECT system greatly simplifies blood collection, stabilization, and shipment while generating DNA yield and quality comparable to whole blood.
No phlebotomist required
Reduce sample collection time and cost
Increase the size of study cohort
Expand the geographical coverage area of study
Simplified sample tracking and workflow integration
The blood-absorbing fiber is permanently attached to a 2D barcoded cap and the unique identifier is maintained throughout the sample processing workflow
Sample collection integrates directly into workflows
Sample collection, stabilization, and extraction tie into your in-house or bioanalytical provider’s pipeline
Comprehensive workflow, designed for biomarker extraction
Acquire sample through a finger-prick without the need for a phlebotomist
Transfer sample to the truCOLLECT device with an FDA approved EDTA-coated capillary
The fiber is permanently attached to a barcoded cap and the identifier is maintained throughout the sample processing workflow.
The truCOLLECT fiber is designed for stabilization of fluidic biological samples including whole blood
The truCOLLECT cap with fiber is inserted into the desiccant container for efficient dry-stabilization, independent of the sample collection environmental conditions.
The sealed container allows for consistent dry-stabilization, and prevents sample-to-sample, and environment-to-sample contamination.
The plastic design and construction ensures robust shipping conditions.
SHIP & STORE
The desiccant container with the dry-stabilized blood sample is ready for ambient temperature shipping via regular mail, courier, or express mail.
The sealed container can also be used for storing the dry-stabilized blood for long-term storage in specially designed containers.
Utilizing Covaris Adaptive Focused Acoustics® (AFA™) technology and optimized reagents, dry-stabilized blood in the truCOLLECT device is actively re-hydrated and cells are lysed to release the DNA.
Efficient biomarker extraction with AFA is comparable to dried blood spot and fresh whole blood samples.
truCOLLECT: Active blood re-hydration and biomarker extraction powered by Covaris Adaptive Focused Acoustics (AFA)
From Left to Right: truCOLLECT cap with fiber, desiccant container, microTUBE-130, and microTUBE-130 with truCOLLECT cap and fiber.
Medical-grade 0.5MHz ultrasonic transducer
Geometrically focused acoustic energy
Short wavelength ideal for processing biological molecules
Non-contact delivery of controlled focused acoustic energy
Acoustically optimized sample vessel materials and design
Consistent sample processing temperature (isothermal)
Patents issued and pending
truCOLLECT-85 Kit (set of 10)
kit contains truCOLLECT cap with fiber, desiccant container, microTUBE™-500, and user manual
truCOLLECT-15 Kit (set of 10)
kit contains truCOLLECT cap with fiber, desiccant container, microTUBE-130, and user manual
In this poster, we introduce truCOLLECT™, a novel blood collection system which does not require a venous blood draw and greatly simplifies blood collection, standardizes dry stabilization, and simplifies shipment while delivering DNA yield and quality comparable to fresh whole blood
Here, we present two innovations that together overcome many of the drawbacks of the current DBS technology: (1) a novel sampling device for collecting capillary blood (truCOLLECT™) that provides integrated sample barcoding, eliminates the need for a drying period before shipment, and yields DNA and protein amounts similar to those seen with fresh blood; and (2) use of Adaptive Focused Acoustics (AFA™) for efficient release of biomarker from truCOLLECT™ devices as well as from conventional DBS (truXTRAC™ DBS). The AFA™-based extraction process is highly automated and allows batch processing with less than 30 min hands-on-time per 96 samples.
Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.