cryoPREP™ Impactors deliver a calibrated and repeatable mechanical force to cryofracture flash-frozen samples; both manual and automated systems are available. There are specific manual and automated cryoPREP Impactors available for use with t-PREP™ or tissueTUBE™ Devices. The controlled, high impact force to tissues biospecimens flash-frozen in a t-PREP or tissueTUBE device results in the dry cryofracture of tissue samples without direct sample contact. The cryofracture of the tissue breaks the tissue into small pieces and introduces cracks in the tissue thereby increasing the surface area and improving lysis with extraction buffers. Combining cryoPREP treatment with AFA Ultrasonication greatly enhances biomolecule extraction enabling increased sample yields, improved integrity, and greater complexity with reagents ideally suited for downstream analytical methods.
Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pomerantz, Jessica Seitzer, Martin L. Koser, Marc T. Abrams, Yan Xu, Nelly A. Kuklin, Paul A. Burke, Alan B. Sachs, Laura Sepp-Lorenzino, Stanley F. Barnett. Quantitative evaluation of siRNA delivery in vivo. RNA. 2010 December; 16(12): 2553-2563. doi: 10.1261/rna.2255810 PMCID: PMC2995415 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
J Tammam, C Ware, C Efferson, J O’Neil, S Rao, X Qu, J Gorenstein, M Angagaw, H Kim, C Kenific, K Kunii, KJ Leach, G Nikov, J Zhao, X Dai, J Hardwick, M Scott, C Winter, L Bristow, C Elbi, JF Reilly, T Look, G Draetta, LHT Van der Ploeg, NE Kohl, PR Strack, PK Majumder. Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol. 2009 November; 158(5): 1183-1195. Published online 2009 September 23. doi: 10.1111/j.1476-381.2009.00389 PMCID: PMC2782329 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782329/
8” Width x 21” Depth x 13” Height (20 cm x 53 cm x 33 cm)
Approximately 26 lbs (13 kg)
100-240 VAC 300 VA, 50-60 Hz
15 to 32C
CE, ETL Mark (for Product Safety), WEEE
Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements”
Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.