S220 Focused-ultrasonicators

with AFA Technology

The S220 Focused-ultrasonicator is a versatile, high power system engineered for pre-analytical sample processing with Covaris’ patented Adaptive Focused Acoustics™. Utilizing a spherical acoustic transducer, specifically designed AFA™ Tubes, and advanced electronics, AFA delivers controlled energy precisely and accurately to sample volumes from 25 μl to 10 ml.

The versatility of the S220 Focused-ultrasonicator makes it possible to bring the advantages of AFA to numerous biological and chemical applications including, DNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization.

The S220 Focused-ultrasonicator is computer controlled by SonoLab™ Software, incorporating preset protocols for standard methods, such as DNA shearing to specific fragment lengths, and easy-to-use-tools for user-defined protocols. The S220 is also compatible with ActiveX control if required for more specialized customer-defined, laboratory automation applications.

Focused-ultrasonicators with AFA Technology operate at high frequencies (500KHz) and, therefore, unlike traditional low frequency laboratory sonicators. AFA is inaudible and does not require sound-proof boxes, hearing protectors, or other unusual precautions for their operation.

The S220 Focused-ultrasonicator  is available in higher power (S220X) and robotic capable (S220R) configurations.


S220 Focused-ultrasonicator

S-Series Datasheet

Feature Benefit
Continuous Temperature Control No heat damage, higher recovery
Non-contact, closed vessel No cross contamination, no aerosols, no clean up
Accurate, Precise, and Controlled acoustic energy Processes and protocols are highly reproducible
Accommodates a broad sample volume range Multiple applications are accommodated in a single instrument
Ultrasonic AFA is inaudible so no sound-proofing or special precautions needed

S220 AFA Ultrasonicator is a versatile tool for a broad range of applications, including:

DNA Shearing for NGS

Chromatin Shearing

Tissue homogenization for:

Cell lysis

Drug Delivery and Formulation

If you are interested in applying Covaris technologies to your specific application please contact us.

Tubes and vessels engineered for AFA compatibility:
AFA™ Tubes

AFA Compatible Kits and Reagents:
t-PREP™ System for Biomarker Extraction
truChIP™ Chromatin Shearing Kits
cryoPREP Extraction Systems

S220 Accessories:
Water Conditioning System
S-Series holders

Technical Specification Description
Model S220 Focused-ultrasonicator
Treatment System Bench-top; high intensity acoustic transducer, temperature monitoring device, circulation pump, water bath with safety enclosure
Treatment Power 100 Watts Average Power
Dimensions 8” Width x 21” Depth x 13” Height (20 cm x 53 cm x 33 cm)
Weight Approximately 26 lbs (12 kg)
Power Requirements 100-240 VAC 500 VA, 50-60 Hz
Operating Conditions:
Ambient Temperature 15 to 32C
Water Bath Temperature +5C to +40C; Controllable
Water Distilled or deionized water only
Computer: Notebook compatible; available with system from Covaris
Operating System Microsoft Windows XP SP3 minimum or Windows 7
Software SonoLab 7
Regulatory Certifications CE, ETL Mark (for Product Safety), WEEE
Safety Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements”
EMC Complies with radio frequency emissions and immunity requirements for Class A Industrial/Scientific/Medical (ISM) equipment under EN 61326-1:2005, as well as EN 61000-3-2:2004 and EN61000-3-3:1995. These standards meet the essential requirements of the EU EMC Directive 2004/108/EC. Additionally, the instrument meets FCC Part 15 Class A radio emissions requirements for the USA and ICES-003 Class A for Industry Canada.