Covaris Introduces a High-Throughput, High-Precision Mixing System

WOBURN, MA—March 6, 2000—Covaris, Inc. announces its innovative High-Throughput sample mixing technique. This is a new application of Covaris¹ enabling technology platform for High-Throughput biology research.

The exCELLerator™system enables non-contact mixing for automated sample preparation and processing. High-Throughput applications that require controlled mixing, dissolving or resuspension can be standardized with this technology. The Covaris Process applies computer-controlled shock wave physics to life sciences. These shock waves can penetrate closed vessels and then converge in a mixing zone. This technology can work with completely closed vessels for enhanced safety of users. Since mixing occurs without the need of stirring implements and in closed vessels, sample-to-sample cross contamination is eliminated. The process may also be used in conjunction with, and to improve the efficiencies of resin, bead, and paramagnetic particle-based mixing processes.

The exCELLerator is designed to accommodate a variety of sample vessels, including tubes, multi-well plates, and microarrays in a random access, individually addressable format. The instrument can be used to mix a single well or a whole multi-well plate in batch mode. Depending on the sample volume, the Covaris system will mix a multi-well plate of samples in less than one minute without operator assistance. For example, with a 1 microliter sample volume the processing time may be less than a millisecond. The Covaris system is amenable to both cell-based processes and biochemical assays.

The exCELLerator system is the leading edge of High-Throughput sample processing technology. It is designed for state-of-the art laboratories that need a reproducible, robust sample mixing process in fields such as toxicology, functional genomics, target validation and proteomics.

Covaris, Inc. is a privately held company founded in 1999 to develop instrument systems based on its proprietary biophysical technology platform. ExCELLerator systems are being installed in High-Throughput laboratories, however, this technology is still open for licensing in specific fields of use. The system can be configured as either a stand-alone, bench-top apparatus or as a module for a robotic-based laboratory.

About Covaris:
Covaris, Inc. is a privately held company founded in 1999 to develop instrument systems based on its proprietary, patent-pending, biophysical technology platform. The technology is based on focused acoustic energy and applications of shock wave physics for advanced and high-throughput applications in biology and medicine.

Contact:
Covaris, Inc.
14 Gill Street, Unit H
Woburn, Massachusetts
USA 01801-1721
Tel: +1 781-932-3959
Fax: +1 781-932-8705
e-mail: info@covaris.com

Computer Controlled Shock Wave Instrument for High-Throughput Sample Preparation

WOBURN, MA—February 2, 2000—Covaris, Inc. announces today its new instrument system for High-Throughput biology research.

The exCELLerator™ E1 system from Covaris standardizes cellular lysis and tissue disruption for automated sample preparation. For the first time, life scientists have a system that can reproducibly deliver mechanical energy to a sample. This is achieved through the precisely controlled generation and pinpoint delivery of shock waves. These shock waves can penetrate closed vessels; this provides sterile handling and enhanced safety for users.

The exCELLerator is designed for use with a variety of sample holders, including tubes and multi-well plates for High-Throughput applications. The system will process a multi-well plate of tissue samples in less than five minutes without operator assistance. With a wide range of user specified temperatures and no need to add lytic chemicals, this powerful acoustic disrupter is gentler to the target molecules, such as nucleic acids and proteins, that researchers need to extract than the current manual or chemical methods. A large variety of samples can be treated including bone, liver, and plant tissues as well as microbes.

The exCELLerator system is the leading edge of High-Throughput sample processing technology. It is designed for researchers who need the greatest precision in sample preparation in fields such as toxicology, functional genomics, target validation, and proteomics. The exCELLerator system is especially valuable for high volume, hard tissue sample preparation where preserving the integrity of extracted molecules is important. The system is currently available either as a stand-alone, bench-top apparatus or as a module for a robotics-based laboratory.

About Covaris:
Covaris, Inc. is a privately held company founded in 1999 to develop instrument systems based on its proprietary, patent-pending, biophysical technology platform. The technology is based on focused acoustic energy and applications of shock wave physics for advanced and high-throughput applications in biology and medicine.

Contact:
Covaris, Inc.
14 Gill Street, Unit H
Woburn, Massachusetts
USA 01801-1721
Tel: +1 781-932-3959
Fax: +1 781-932-8705
e-mail: info@covaris.com