Uniscience do Brasil / Covaris partner to distribute in Brazil

Woburn Massachusetts, USA and São Paulo Brazil

Covaris Inc., has appointed Uniscience do Brasil as its authorized distributor in Brazil. Uniscience will supply the Brazilian LifeScience,drug discovery and development markets with Covaris sample-preparation products including, AFA Focused-ultrasonicators and consumables, as well as application specific reagent kits for NGS, ChIP, Proteomics, and Pharmaceutical applications.
“We are very pleased to be partnering with Uniscience do Brasil to bring Covaris Adaptive Focused Acoustic™ technology to LifeScience,drug discovery and drug development researchers in Brazil,” said Jim Laugharn, Covaris Founder and CEO. “Uniscience has a strong reputation as a market leader in the region and we are looking forward to a very positive business relationship.”
“Covaris is a leader in the area of sample preparation for drug discovery. Covaris and Uniscience complement each other and will build a strong business franchise in Brazil,” said Sergio Joelsons, Uniscience CEO and President.

About Uniscience do Brasil
Based on a pioneering initiative, Uniscience do Brasil (www.uniscience.com) began its activities 29 years ago, aiming to combine technological expertise with development potential. Uniscience partners to integrate intelligent solutions in equipment, reagents, and accessories for the areas of Biotechnology, Diagnostic, and Molecular Biology. Unscience do Brasil’s mission is to act as a partner to our customers by providing reagents, equipment, and supplies high-quality research molecular biology. Our vision is to be recognized as the biotechnology market leader in Brazil with the most complete and reliable product line.

About Covaris
Covaris, Inc. (www.covarisinc.com) provides advanced sample preparation systems for life and analytical science. Covaris sample prep technologies support a wide variety of applications including Next-Generation Sequencing, ChIP, proteomics, formulations, and compound management. Our patented Adaptive Focused Acoustic™ (AFA™) employs highly controlled bursts of focused high-frequency acoustic energy to efficiently and reproducibly process samples in a temperature-controlled and non-contact environment. AFA is the industry standard for DNA shearing, and is used by major genome centers and academic institutions worldwide. It brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, which is based on shock wave physics, delivers controlled, precise, and accurate acoustic energy to biological and chemical samples.

For additional information, please contact:
Brian Paras
Covaris Inc.
14 Gill St Unit H.
Woburn, Massachusetts, USA 01801
bparas@covarisinc.com
001 781 932 3959 ext 206

Life Technologies to supply new Covaris DNA fragmenting products for Ion Torrent Semiconductor Sequencers

Covaris, Inc., today announced that it has signed an agreement with Life Technologies Corporation enabling Life Technologies to offer the Covaris M220 Focused-ultrasonicator system to users of the Ion Torrent Next-Generation Sequencing platforms.
Compact, cost effective, easy-to-use, and quiet; the M220 Focused-ultrasonicator is the ideal fragmenting system for PGM™ and Proton™ users. The M220 includes integrated cooling, eliminating the extra cost and space required for an external chiller, as well as reducing startup time to less than 2 minutes. Using the acoustically engineered Covaris’ microTUBE and miniTUBE consumables, the M220 provides the high quality DNA libraries researchers demand and have come to expect from Covaris.
According to Jim Laugharn, Covaris Founder and CEO; “Today’s highly sensitive NGS systems are clearly exposing the importance of controlled, isothermal DNA fragmentation. This is even more important when unbiased and uniform deep coverage with maximum library complexity is required to maintain clinical relevance”.
Covaris AFA is the standard method for DNA shearing in major genome centers worldwide and the M220 Focused-ultrasonicator is the latest AFA product providing the same performance benefits as the market leading S-series and E-series systems in a smaller, more compact unit. Other applications for the M220 include Chromatin Shearing, RNA Shearing, DNA extraction from FFPE samples, and biomarkers extraction from tissue samples.
For more information contact:
Simon Price, Covaris
+1 781 932 3959

Industry-Standard Covaris DNA Shearing Performance for Every Laboratory – Large or Small

The M220 Focused-ultrasonicator is the newest DNA shearing system from Covaris.

The M220 is designed for Next-Gen sequencing applications. Using highly controlled AFA™ (Adaptive Focused Acoustics) technology, the M220 reproducibly shears DNA into random fragments ranging from 200bp to 3.0kb.

Compact, cost effective, and easy-to-use, the M220 “Personal Fragmenter” is the ideal shearing system for MiSeq™ and PGM™ users. The M220 includes integrated cooling, eliminating the extra cost and space required for an external chiller, as well as reducing startup time to under 10 minutes. Using the acoustically engineered Covaris’ microTUBE and miniTUBE consumables, the M220 provides the high quality shearing results researchers have come to expect from Covaris.

According to Jim Laugharn, President and CEO “Prior to Covaris AFA, the pre-analytical step to uniformly fragment DNA under controlled conditions was difficult to enable unbiased and uniform deep coverage while maximizing library complexity and quality; both critical for clinical relevance. Today’s highly sensitive NGS systems are clearly showing the biological relevance of controlled, isothermal fragmentation.”

The M220 provides the same performance benefits as the market leading S-series and E-series systems from Covaris including, precise energy control for user-selectable DNA fragment lengths, an isothermal process eliminating heat-induced molecular damage, closed vessels for highest sample recovery, and a non-contact process that eliminates cross contamination and clean-up. The M220 was recently released at SLAS and will be presented with performance data at AGBT 2012. Additional applications for the M220 are currently in development, such as biomarker extraction and chromatin shearing.

For additional information, please contact:
Brian Paras
Covaris Inc.
14 Gill St Unit H.
Woburn, Massachusetts, USA 01801
bparas@covarisinc.com
001 781 932 3959 ext 206

Covaris Consumable Shears DNA to 6kbp – 20kbp Fragments

g-TUBE, the latest innovation from Covaris, is a single-use consumable that enables scientists to shear genomic DNA into selected fragments sizes ranging from 6kbp to 20kbp. The only equipment needed is a compatible bench-top centrifuge and a pipette.

g-TUBE uses centrifugal force (the “g” in g-TUBE) to push the sample through a precisely manufactured orifice in the embedded ruby. This produces shearing forces in the sample that fragment the DNA. Fragment size is selected by adjusting the centrifuge rotor speed which alters the flow rate through the ruby and thus the shearing forces. Higher centrifugation RPM will produce shorter fragments and the protocol provide by Covaris contains the settings needed to select a fragment size between 6kbp and 20kbp.

Remarkably, the entire process takes only 3 minutes and up to 24 samples can be processed simultaneously.

Covaris now offers a complete range of products covering all sequencing needs from 100 bp to 20 kbp and consolidates its status as the DNA shearing gold standard.

For additional information, please contact:
Brian Paras
Covaris Inc.
14 Gill St Unit H.
Woburn, Massachusetts, USA 01801
bparas@covarisinc.com
001 781 932 3959 ext 206

Covaris to Supply the BGI with High-Throughput DNA Shearing for Next-Generation Sequencing

Beijing, China and Woburn, Massachusetts, USA—July 11, 2011—BGI (Beijing Genomics Institute) and Covaris, Inc. today announced a deal that will integrate Covaris’ Adaptive Focused Acoustics™ AFA™ DNA shearing technology across several BGI laboratories in China. BGI will utilize the Covaris LE220 parallel processing, multi-sample platform to fragment DNA samples for Next-Generation Sequencing.

“BGI will use Covaris instrumentation and consumables in our DNA library construction process. Our laboratories will process a large volume of samples on a daily basis, so the multi-sample format provided by the LE220 was a key consideration for us,” said Mr. Zongze Wu, Technical Engineer, DNA Library Construction Group at BGI. “The Covaris LE220 instrument offers both high-throughput capability and consistent high-quality results for our downstream applications”.

“Beijing Genomics Institute is a recognized world leader in the field of genomic research, and Covaris is delighted to be working together with BGI to provide researchers with high-throughput Next Generation sample preparation.” said Jim Laugharn, Covaris President and CEO. “High quality, reproducible sample preparation is the critical first step in improving down-stream analytical results. The unique and highly controlled Covaris systems set the standard for today’s rapidly advancing analytical technologies and sophisticated assays. For example, isothermal Covaris processes will be beneficial for proteomic-related studies such as ChIP”.

About LE220
The award winning LE220 high-performance focused ultra-sonicator is specifically designed for high-throughput operations (such as the Next-Gen Sequencing at BGI) that require high quality DNA shearing. The LE220 utilizes patented AFA technology to concurrently shear multiple DNA samples. AFA technology from Covaris improves recoveries, increases efficiency, and provides high-quality reproducible DNA shearing results.

About BGI
BGI (www.genomics.cn) was founded in Beijing on Sept 9th, 1999 with the mission of supporting the development of science and technology, building strong research teams, and promoting the development of scientific partnership in the genomics field. BGI has created a unique research center with industrialized infrastructure to support innovative development and applications. Sticking to principles of good faith and social responsibility, BGI has made substantial contributions in the fight against SARS and aided in disaster relief for the tsunami in Southeast Asia, all of which greatly enhanced the international reputation of China. Throughout its short history, BGI has created an institutional structure that is characterized by systematization and innovation, institutional integration, technological platform development, and product commercialization. This collaborative system, all of which is powered by the study of genomics, enables BGI to rapidly move from basic research to application.

About Covaris
Covaris, Inc. (www.covarisinc.com) provides advanced sample preparation systems for life and analytical science. Covaris sample prep technologies support a wide variety of applications including Next-Generation Sequencing, ChIP, proteomics, formulations, and compound management. Our patented Adaptive Focused Acoustic™ (AFA™) technology is the industry standard for DNA shearing, and is used by major genome centers and academic institutions worldwide. AFA brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, which is based on shock wave physics, delivers controlled, precise, and accurate acoustic energy to biological and chemical samples.

For additional information, please contact:
Brian Paras
Covaris Inc.
14 Gill St Unit H.
Woburn, Massachusetts, USA 01801
bparas@covarisinc.com
001 781 932 3959 ext 206

Covaris Introduces Bench-top, AFA-based Process Technology

Ground-breaking, enabling tool for both formulation of poorly soluble medias and new drug delivery systems.

Woburn, MA—March 25, 2011—Covaris Incorporated today announced the introduction of the Bench-top SF220 High Performance Formulation Processing System.

The SF220 system was designed to extend the company’s groundbreaking Adaptive Focused Acoustics (AFA) technology to higher volume sample processing. With the ability to process sample volumes from microliters through tens of liters, larger volume application areas such as Pre-clinical formulation, drug delivery systems, and biological processes (such as cell lysis, sonoporation, or transfection) can now “scale-up” the advantages of the proven AFA technology.

The Covaris SF220 system provides a solution for the problem of poorly soluble API’s using the proprietary Covaris AFA Technology. For example, adoption of the AFA-based SF220 system for preparation of DMPK formulations has been shown to improve quality of the studies by increasing the bioavailability, while reducing subjective content and improving operational efficiency. Using AFA to accelerate dissolution can improve both the quality and efficiency of the drug development process, with unparalleled reproducibility, precision, and speed. Demonstrated increases of solubility of over 90% have been achieved, while concurrently reducing the process time from over 2 days of stirring to under 3 minutes, and increasing the available API by over 2.5x due to a dramatic reduction in API degradation. According to Jim Laugharn, Founder and CEO “We at Covaris are very excited about the introduction of the new systems to meet the “pent-up demand” our current customers have for processing larger sample volumes with AFA technology.” At present, Covaris has installed over 1,500 systems in over 30 countries worldwide.

AFA has also been demonstrated to formulate monodisperse, nano-emulsions with mean particle sizes of 20nm and an index below 0.100. Liposomes can be produced using a simple lipid/water combination with the resulting single populations below 100nm. The ability to reduce particle size of a crystalline API in water to below 15nm is possible. All results were achieved using Adaptive Focused Acoustics TM (AFA) with very fast process times, non contact, and isothermal operating conditions.

The Bench-top scale SF220 system is currently available from Covaris. Pilot scale systems are currently in development.

About Covaris, Inc.
Covaris, Inc. is a rapidly growing life science instrument company. Its proprietary instrument platform, based on patented Adaptive Focused Acoustic (AFA) technology brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, based on shock wave physics, delivers controlled, precise and accurate energy to biological and chemical samples. The process is non-contact, isothermal and rapid. Leading pharmaceutical and biotechnology companies worldwide are using Covaris instruments for DNA shearing, RNA extraction, Compound Dissolution and much more.

Information about Covaris is available at http://www.covarisinc.com.

Contact:
Carl Beckett
General Manager, Flow Division
Covaris, Inc.
14 Gill Street, Unit H
Woburn, Massachusetts
USA 01801-1721
Tel: +1 781-932-3959 ext 231
Fax: +1 781-932-8705
e-mail: cbeckett@covarisinc.com
web: www.covarisinc.com