We present a new DNA shearing vessel, the Covaris oneTUBE™ that is optimized for low DNA input and allows single tube DNA shearing and NGS library preparation. This new engineered polymer vessel incorporates features that effectively control acoustic cavitation to enable reproducible and precisely tuned hydrodynamic shear forces. Its low binding surface guarantees high DNA recovery […]
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Entries by Covaris
While most NGS automation workflows have focused on Library Preparation and Target Enrichment protocols, there have been only a few commercial solutions presented around the initial DNA sample transfer from the Covaris microTUBE consumables. Here we introduce an automated workflow for extracting sheared DNA samples from a 96 microTUBE Plate and 8 microTUBE Strip using the […]
Woburn, MA – November 14, 2017 – Today, Covaris Inc. announced the release of the 96 oneTUBE-10 AFA Plate, which enables scalable and simplified workflows by leveraging Covaris’ gold standard focused-acoustic technology to meet rapidly increasing Next-Generation Sequencing (NGS) demands for high-throughput and low-input library preparation. By using the oneTUBE-10 offering, transfer steps within the […]
This document provides users with a complete set of protocols that encompass all Covaris Adaptive Focused Acoustics™ (AFA) instruments for DNA shearing to 150 to 200 bp with 50 to 55 µl of sample volume, to be readily compatible with the Agilent SureSelect Target Enrichment System (XT or XT2). The goal is to provide the most […]
DNA Shearing with ME220 Focused-ultrasonicator Quick Guide
Safety Data Sheet for B3 Buffer
Safety Data Sheet for the AFA Conditioning Buffer
This work describes a protocol for chromatin immunoprecipitation (ChIP) using a mature mouse T-cell line. This protocol is suitable to investigate the distribution of specific histone marks at specific promoter sites or genome-wide.
Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.