AFA-Nanocrystalpdf_1a

Control “bottom up” API Nucleation and Crystal Growth

In either a batch or a continuous flow solvent/anti-solvent reaction process, AFA-Energetics™ enables temperature-controlled nanoparticle formation that would otherwise yield large, highly variable, unusable particle sizes

  • Formulate crystalline nano- OR micro-sized particles
  • Accelerate kinetic energy reactions with extreme mixing velocities in isothermal conditions with a non-contact process
  • Integrate PAT for automated, real time feedback, and Quality Control

The AFA-Energetics Zone
… enables batch-to-continuous processes

cvAFAprocessingVessel

 

designed for extreme turbulence
AND
precise temperature control
IN A
non-contact environment

* flow cell OR batch vessel

 

emulsion3

 

 

 

 

 

Ibuprofen with AFA produces 700 nm particles while untreated samples are large, uneven clumps.

Flow Apparatus Example

Flow

User Defines Crystal Size in Continuous Flow

PIPChart2Chart2

 

 

 

 

 

 

 

 

 

 

 

 


[tabs title=”” active=”0″ event=”click”]

[tab title=”Features
& Benefits”]

Unprecedented thermal control

Enable sample processing temperatures from 4° C to 60° C

Computer Controlled

Automated, computer controlled processing

Scalable

From 100 μL batch mode to continuous process streams

Non-contact

Eliminates risk of contamination

[/tab]

[tab title=”Products”]

Covaris S-Series Focused-ultrasonicator
Single vessel processing from 300µL through 18mL sample volumes:
• Discovery
• Animal dosing
• Method development
AFA Process Vessels
p-vessels_3
AFA Process Vessels: optimized for AFA processing
From 100µL to continuous flow manufacturing
• 100% self contained
• Inert materials
• Designed for maximum acoustical effectiveness

[/tab]
[tab title=”Crystallization
Protocols”]

AFA-Nanocrystal™ Production Batch-scale (2mL) Felodipine Preparation Protocol

AFA-Nanocrystal™ Production Batch-scale (2mL) Indomethacin Preparation Protocol

AFA-Nanocrystal™ Production Batch-scale (2mL) Cinnarizine (CNZ) Preparation Protocol

Preparation of Felodipine Nanosuspension (2 ml) by crystallization through AFA technology
[/tab]

[tab title=”References”]

Continuous nanoparticle production using focused acoustics

Continuous flow AFA-Nanocrystal™ production using a solvent/antisolvent method.

Poster abstract for 2015 AIChE Annual Meeting Nov 8-13, Salt Lake City, UT

 

Controlling Crystallization with Adaptive Focused Acoustics

Poster: He et al., 2013. Flow Chemistry Congress, Boston, MA

 

Crystal Nucleation of Poorly Soluble Drugs: Experimental Results and New Knowledge
Master’s Degree Thesis: Alexandra Franzén, Department of Chemistry, Lund University (2011).

 

WO2011/102787 A1

Patent: Lindfors et al., 2011. Process for Preparation of Crystalline Nano-particle Suspensions.

[/tab]
[tab title=”Case
Studies”]

Case Study 1: Crystallization by Solvent / Anti-solvent

Case Study 2: Cooling Crystallization

[/tab]

 

Click image to enlarge

[/tab]
[/tabs]